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New lab members!

We are excited to welcome new lab members Amber (PhD student), Eri and Noah (master students) that are starting in october and november 2022!

NWO Vidi Grant for Agathe!

Agathe received 800000€ in funding from the NWO for her project “burning bridges and moving on”. She will be looking at hiring at PhD student and a postdoc to investigate the mechanism or formation and role of cytoplasmic bridges in mouse embryonic stem cells!
https://www.nwo.nl/en/news/101-researchers-receive-nwo-vidi-grant-worth-800000-euros

Snježana Kodba has stayed in the lab!

On February 1st Snježana has started in the lab! She investigates the molecular regulation of abscission in stem cells. Welcome!

The Chaigne lab has (virtually) opened its doors!

In February I will welcome our first PhD student!

From January 2022 I will be an Assistant Professor at Utrecht University in the department of Cell biology, neurobiology and biophysics!

I have a fully funded PhD position to work with me on the mechanism underlying cytoplasmic bridges maintenance and abscission during fate transitions, using mouse embryonic stem cells. Get in touch if you’re interested!

New paper online on spindle positioning and size control in 3D embryonic colonies!

My new paper is online in the Journal of Cell Science! Along with my co-authors Matthew Smith (for the 3D segmentation), Rocío Lopez-Castevany (for the NuMA immunofluorescence experiments), Edouard Hannezo (for the measurments of the spindle motility in 3D) and Kevin Chalut and Ewa Paluch (for the project supervision), we mouse embryonic stem cells (ESCs), which live in 3D colonies, as a model to investigate the control of daugther cell size after cell division in 3D. We show that at the periphery of 3D colonies, ESCs display high spindle mobility and divide asymmetrically. Our data suggest that enhanced spindle motility are due to unequal distribution of the cell–cell junction protein E-cadherin between future daughter cells. When cells progress towards differentiation, the division becomes more symmetric, with more elongated shapes in metaphase and enhanced cortical NuMA recruitment in anaphase. We propose that in 3D contexts, the geometry of the cell and its contacts with neighbors control division orientation and symmetry.

Inaugural BSCB Postdoctoral Researcher Medal

It is truly an honor to be the recipient of the inaugural medal for the British Society for Cell Biology Postdoctoral Researcher Medal! I have had a blast amongst the great UK Cell Biology Community and I can’t wait for the next meeting!

Catch my talk at the virtual 2020 ASCB!

I will be presenting bits of my work at Cellbio2020. Registration is free and it’s all online! You can find the abstract here. It has been pre-recorded so you might even be able to catch my neighbours hammering something to their wall and my bulldog snoring. I will be here for the Q&A, and offer complementary bulldog pictures upon reasonable request!

Watch my talk at the “from Cells to Embryos” meeting organised by the ITMO BCDE, the french society for cell biology and the french developmental biology society

If you were registered for this meeting, all the talks will be recorded.

Paper out in Dev Cell!

My main postdoc paper is now out in Dev Cell.

Paper accepted!

My new paper on the role of abscission in exit from naive pluripotency just got accepted! Stay tuned for more updates.

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